Electronic Machine Intelligence Lab (EMIL)

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You are here: Electronic Machine Intelligence Lab » 1. ISFET Array for Detecting a Single Nucleotide Polymorphism
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geneonyxmar302012:start [2015/05/06 03:49] – magierogeneonyxmar302012:start [2015/05/06 03:53] (current) – magiero
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 • Ostensibly the primer (of length n) binds to the DNA at the predetermined spot (defined by the sequence of the primer itself).\\ • Ostensibly the primer (of length n) binds to the DNA at the predetermined spot (defined by the sequence of the primer itself).\\
 • The chamber containing the nt that complements the SNP (in the n+1 position) will then undergo a hydrolisis reaction that drops the pH and is detected by an ISFET.\\ • The chamber containing the nt that complements the SNP (in the n+1 position) will then undergo a hydrolisis reaction that drops the pH and is detected by an ISFET.\\
-• +• The ISFET's (one per chamber) are **cleverly interfaced** (__this is basically the invention__) to four differential amps (based on knowledge of allele possibilities in mammals) which produce signal combinations such that the type of SNP encountered can be identified.\\ 
 +• This arrangement reduces the effect of offsets and the need for extensive, high-resolution sampling.
  
 ==== - Detailed Description ==== ==== - Detailed Description ====
geneonyxmar302012/start.1430884150.txt.gz · Last modified: by magiero