Electronic Machine Intelligence Lab (EMIL)

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You are here: Electronic Machine Intelligence Lab » 1. ISFET Array for Detecting a Single Nucleotide Polymorphism
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geneonyxmar302012:start [2015/05/06 03:52] – magierogeneonyxmar302012:start [2015/05/06 03:53] (current) – magiero
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 • Ostensibly the primer (of length n) binds to the DNA at the predetermined spot (defined by the sequence of the primer itself).\\ • Ostensibly the primer (of length n) binds to the DNA at the predetermined spot (defined by the sequence of the primer itself).\\
 • The chamber containing the nt that complements the SNP (in the n+1 position) will then undergo a hydrolisis reaction that drops the pH and is detected by an ISFET.\\ • The chamber containing the nt that complements the SNP (in the n+1 position) will then undergo a hydrolisis reaction that drops the pH and is detected by an ISFET.\\
-• The ISFET's (one per chamber) are **cleverly interfaced** (this is basically the invention) to four differential amps (based on knowledge of allele possibilities in mammals) which produce signal combinations such that the type of SNP encountered can be identified.+• The ISFET's (one per chamber) are **cleverly interfaced** (__this is basically the invention__) to four differential amps (based on knowledge of allele possibilities in mammals) which produce signal combinations such that the type of SNP encountered can be identified.\\
 • This arrangement reduces the effect of offsets and the need for extensive, high-resolution sampling. • This arrangement reduces the effect of offsets and the need for extensive, high-resolution sampling.
  
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