Electronic Machine Intelligence Lab (EMIL)

Priority: Mar 30, 2012

(from WO 2013/144580 A1)

• 99.9% of the code is similar among the human population and it is the remaining 0.1% that makes the differences. • Single Nucleotide Polymorphism is a single mutation of a gene that can be found in more than 1% of a population. • How to detect if a particular sequence is in the genome? If a primer attaches then it matches and it can be extended. This extension of a primer on the target releases pyrophosphate and H+ ions [3]. Therefore, by detecting whether the acidity in the analyte has increased or not, it is possible to determine whether extension has occurred or not; and consequently whether the designed sequence was matched or not. • …the presently used platform for ISFETs has made them power and memory intensive. • The presently used platforms are required to process large amounts of data in order to provide a yes/no answer saying a particular polymorphism is detected in the target DNA or not. These intensive requirements are mainly due to the existence of sources of error that need to be cancelled out in the measurement.