Differences

This shows you the differences between two versions of the page.

--- oxfordapr202009b:start [2015/02/05 16:15] – magiero
+++ oxfordapr202009b:start [2015/11/06 02:42] (current) – magiero
@@ Line 27: / Line 27: @@
 • [0099] **Output pump** 34 pumps fluids out of the sensor through **outlet channel** 36 (connected to **waste reservoir** 35 on the bottom).\\
 • [0100] **Selector valve** 45 connects the sensor to either the supply or the waste reservoir.\\
+{{ cartridge2bot.png?300}}
+{{cartridge2.png?300}}
+{{wellplate.png?200}}
 ==== - Three Sensor-on-PCB Alternatives [0148] - [0151] ====
@@ Line 51: / Line 55: @@
 An example is the [[https://thermal.ferrotec.com/index.php?id=module_detail&mod_id=69|Ferrotec Thermoelectric Module]]. It may be mounted underneath the cartridge.\\
 • [0159] The circuits two main functions are **signal processing** and **control**.\\
+=== - Signal Processing Function [0160] - [0175] ===
 • [0160] Signal processing is distributed between the internal board 50 and the embedded processor 51.\\
 {{ moduleblock.png?500}}
@@ Line 71: / Line 77: @@
 • [0170] Additionally, the pipeline may classify the event and output data may represent the classification of the event.  In the context of poly nucleotide measurements this may be referred to as **base calling**.\\
 • [0171] The pipeline also produces output data that is **quality data** representative of the quality of the output data that represents the results of the biochemical analysis.  This may represent a probability of the detection and/or classification of the events being incorrect.\\
+• [0174] The processing module 73 may also derive and store quality control metrics representing parameters of the biochemical analysis itself.\\
+• [0175] Could also do some of the pipeline work on the FPGA 72 on the internal board 50.\\
+=== - The Control Function [0176]-[0203] ===
+• [0176] The control function is distributed between the internal board 50 and embedded computer 51.\\
+• [0177] The control function includes a **controller** 58, for example a [[http://www.arm.com/products/processors/cortex-m/cortex-m3.php|Cortex M3 microcontroller]], provided on the internal board 50.\\
+• [0178] Controller 50 itself controlled by **control module** 80 implemented in embedded computer 51.  50 and 80 communicate via RS232 81.\\
+• [0201] The analysis apparatus 13 (where is this 13?!?!?!) may contain **control DNA** spiked into real samples.  Data from the control DNA can be used to adjust and refine the algorithms.
+==== - Cluster of Modules [0204] - [0243] ====
+==== - Manner of Module Networking [0244] - [0251] ====
+==== - Implementation Examples [0252] - [0260] ====
+==== - Specifics on Sequencing Example 1 [0261] - [0275] ====
+==== - Details of Biochemical Analysis that can be Performed [0276] - [0298] ====
+• [0282] nanopore-assisted sequencing by hydridisation; strand sequencing; and exonuclease-nanopore sequencing\\
+• [0284]  External circuitry can then perform measurements of DNA passing through each and every nanopore in the array **without the synchronization of base addition** to each nanopore in the array, i.e. each nanopore is free to process a single DNA strand independently of every other, for example as disclosed in [[oxforddec192007:start | Dec. 19, 2007 patent]].\\
+• [0284] Having processes one strand, each nanopore is also then free to begin processing a subsequent strand.\\