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--- geneonyxdec202011:start [2015/05/06 18:31] – magiero
+++ geneonyxdec202011:start [2015/05/06 18:46] (current) – magiero
@@ Line 26: / Line 26: @@
 • The genetic era now opens up the possibility to utilise a deeper understanding of genetics in a customised, i.e. person-specific, way.\\
 • A single-nucleotide polymorphism (SNP) found in the target //(i.e. molecule to be affected)// of an active ingredient //(i.e. the key molecule in the drug)// provides information on the quality of the expected response\\
-• //Use cross-validation of biological target// \\
+• //Use __CROSS-VALIDATION__ of biological target// \\
 • This method uses detection of SNP to estimate protein-protein interaction between an ingredient and its direct or indirect target.\\
 • **As previously discussed**, detecting SNPs to evaluate particular molecule efficacy in a biological pathway is known and is used in pharmacogenetics.\\
@@ Line 50: / Line 50: @@
 • A "functional" SNP is one with a SIF of 5 is chosen.\\
-^ Ingredient ^ Target  ^ SNP ID    ^ pathway ^ target ^SNP  ^ ingredient ^ tion >0.05 ^	of yes
+^            ^         ^           ^ Target is a    ^        ^ Proven    ^ Disruptive ^ High freq.     ^ Total  ^
-| Niacin     | HM74    | rs2454726 | yes     | yes    | yes | yes        | yes        | 5 |
+^            ^         ^           ^ major molecule ^ Direct ^ effect of ^ effect for ^ in the pop-    ^ score  ^
-| Collagen   | MMP-11  | rs1799750 | yes     | yes    | yes | yes        | yes        | 5 |
+^ Ingredient ^ Target  ^ SNP ID    ^ in the pathway ^ target ^ the SNP   ^ ingredient ^ ulation >0.05  ^ of yes ^
+| Niacin     | HM74    | rs2454726 | yes            | yes    | yes       | yes        | yes            | 5      |
+| Collagen   | MMP-11  | rs1799750 | yes            | yes    | yes       | yes        | yes            | 5      |
@@ Line 78: / Line 79: @@
 === - 5: Correlation between ingredients and efficacy associated to SNP ===
+• It can now be determined if an ingredient is efficient or not when affected by a specific SNP(s) in its target (the aforementioned __CROSS-VALIDATION__?).\\
+• The final decision reflects the previously determined efficacy of the ingredient.\\
+• If the target is not functional the ingredient will not be recommended. (i.e. customer's SNP not receptive to ingredient)\\
+• In contrast, if the target is not affected by the SNP the ingredient will be recommended (i.e. just a "normal" SNP)\\
+• If the SNP provides again enhanced efficacy of an ingredient, the dosage of this ingredient might be considered before being recommended\\
+• taken into consideration is the genotype identified by the test. This will affect the correlation given on the efficacy of the test\\
 === - 6: Application: Selection of a group of SNPs associated with the composition of a cosmetic product and its outcome ===